Nesrine Amdouni1, Ikram Chamtouri1, Asma Ben Abdallah1, Walid Jomaa1, Khaldoun Ben Hamda1, Faouzi Maatouk1

1CHU FAttouma Bourguiba Monastir, Monastir, Tunisia

Background:
Anemia is becoming a common comorbidity factor among patients with STEMI. The aim of this study was to analyse the prevalence and the impact of anemia on prognosis and mortality in these patients.

Method(s):
We retrospectively included 352 patients with STEMI, who were enrolled between January 2000 and March 2017 in cardiology B deparment of Fattouma Bourguiba Hospital. According to the World Health Organization, anemia was defined as serum hemoglobin level < 13g/dl for men and < 12g/dl for women. It was devided into mild, moderate, and severe anemia. Anemic patients were compared with no-anemic patients for clinical, prognosis and mortality features.

Result(s):
A total of 352 patients were included in the analysis. Mean age was 60 ± 11.56 years with marked male predominance (84%). Anemia was present in 133 patients (37.8%) of whom 108 had mild anemia, 16 moderate anemia, and 8 severe anemia. Anemic patients were significantly older (p=0.042) and had higher prevalence of comorbidities including hypertension, diabetes mellitus, cerebrovascular diseases than no-anemic patients. Lower hemoglobin levels were significantly associated to higher prevalence of cardiogenic chock (p=0.021), severe ventricular arythmia (p=0.014). Moderate to severe anemia was related with a higher in-hospital mortality (p=0.006) compared to mild and no-anemic patients. Its associated factors were smoking (p=0.038), diabetes mellitus (p=0.042), renal failure (p<0.001), and heart failure on admission (p<0.001).

Conclusion(s):
Presence and severity of anemia is an important predictor of higher in-hospital mortality in patients with STEMI.  Unfortunately, treatment of anemia in cardiovascular disease lacks clear targets and specific therapy is not defined.